Dexamethasone palmitate was incorporated into a lipid emulsion (Intralipid, Intralipos) and was injected into rats, and its distribution in the
Purpose: Dexamethasone palmitate (DXP) is a lipophilic prodrug of dexamethasone (DXM), a potent cortico- steroid used to treat a variety of ophthalmic diseases
Liposome-incorporated dexamethasone, dexamethasone palmitate (DP), shows greater efficacy against macrophages as compared to dexamethasone sodium phosphate
Keywords: epidural space, injections, lidocaine, local anesthetics is not commonly used for an epidural injection, and its safety remains unclear
5 mL of saline and
Compared to dexamethasone, DP is more readily taken up by Targeted delivery of dexamethasone to inflamed tissues using nanoparticles is much-needed to improve its efficacy while reducing side effects
In another attempt to enhance the activity and safety of intravitreally administered corticosteroids for the treatment of macular edema, dexamethasone−palmitate (DXP) emulsions were reported by Finally, an emulsion was used to administer dexamethasone in the form of a palmitate prodrug in the vitreous by intravitreal injection (Daull et al
The aim of the study was to characterize the sustained release capacity (in rabbit), efficacy (in rat and rabbit), and safety (in rabbit, cat, and minipig) of intravitreal (IVT) DXP
The unloaded NPs and DXP-NPs were prepared by the solvent emulsion evaporation technique, varying the amount of initial DXP in the formulation
An arthritis rat model was established via
Compared with dexamethasone, DXP has a stronger anti-inflammatory effect, longer duration of action and fewer adverse effects
dexamethasone phosphate, or more lipophilic for administration as injectable emulsions, e